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Title: Domestic swine in a visceral leishmaniasis endemic area produce antibodies against multiple Leishmania infantum antigens but apparently resist to L. infantum infection
Other Titles: Acta Tropica
Authors: Silva, Evandro Moraes
Antunes, Fabiana Rodrigues
Rodrigues, Marcio Silva
Julião, Fred da Silva
Lima, Artur Gomes Dias
Sousa, Valderez Lemos de
Alcântara, Adriano Costa de
Reis, Eliana Almeida Gomes
Nakatani, Maria
Badaró, Roberto José da Silva
Reis, Mitermayer Galvão
Carvalho, Lain Carlos Pontes de
Franke, Carlos Roberto
Keywords: Visceral leishmaniasis;Pig;Immune response;Experimental infection
Issue Date: 2006
Publisher: Acta Tropica
Abstract: In order to investigate whether pigs can be infected by Leishmania infantum, a serological and parasitological study was carried out on swine in the Jequié municipality, Northeast of Brazil. Anti-Leishmania infantum antibodies were detected in 37 out of 92 swine (40.2%), by two different assays: an anti-L. infantum lysate and an anti-K39 recombinant protein ELISA. An experimental study was also carried out to verify the susceptibility of domestic pigs to L. infantum infection. Three sows inoculated with 108 stationary-phase infective L. infantum promastigotes (26% metacyclic promastigotes) per kilogram of body weight produced anti-Leishmania antibodies until the end of the experiment, 11 months later. No parasites, however, could be visualized through optical microscopy of spleen, liver and bone marrow or by in vitro culture of these organs. Homogenates of these organs were also inoculated in hamsters, without producing infection. No Leishmania DNA was detected by polymerase chain reaction (PCR) in sand flies fed on these animals. The results indicate that domestic pigs bitten by L. infantum-infected vectors in the endemic area do not display a full infection pattern, and the positive association in endemic areas between the presence of swine and infection in canines may not be ascribable to the former acting as a parasite reservoir.
Description: RESTRITO
URI: http://www.repositorio.ufba.br/ri/handle/ri/6523
ISSN: 0001-706X
Appears in Collections:Artigos Publicados em Periódicos (EMV)

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