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|Title: ||HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis|
|Other Titles: ||Brazilian Journal of Medical and Biological Research|
|Authors: ||Lyra, André Castro|
Pinho, João Renato Rebello
Saraceni, C. P.
Braga, Eduardo Lorens
Pereira, J. E.
Zarife, Maria Alice Sant'anna
Lyra, Luiz Guilherme Costa
|Keywords: ||Acute hepatitis;Hepatitis E;TTV;GBV-C/HGV;Genotype;Brazil|
|Issue Date: ||May-2005|
|Abstract: ||he aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as controls. IgM and anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial kits. TTV and GBV-C/HGV were detected by nested PCR; genotyping was done by sequencing and phylogenetic analysis. Anti-HEV IgG was present in 38, 10 and 17% of patients with hepatitis A, B and non-A-C. Four patients with hepatitis A and 1 with non-A-C hepatitis also had anti-HEV IgM detected in serum. TTV was detected in 21% of patients with acute hepatitis and in 31% of donors. GBV-C/HGV was detected in 9% of patients with hepatitis, and in 10% of donors. We found TTV isolates of genotypes 1, 2, 3, and 4 and GBV-C/HGV isolates of genotypes 1 and 2. Mean aminotransferase levels were lower in patients who were TTV or GBV-C/HGV positive. In conclusion, the detection of anti-HEV IgM in some acute hepatitis A cases suggests co-infection with HEV and hepatitis E could be the etiology of a few cases of sporadic non-A-C hepatitis in Salvador, Brazil. TTV genotype 1, 2, 3 and 4 isolates and GBV-C/HGV genotype 1 and 2 strains are frequent in the studied population. TTV and GBV-C/HGV infection does not appear to have a role in the etiology of acute hepatitis.|
|Description: ||p. 767-775|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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