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Title: Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors
Other Titles: Journal of Molecular Histology
Authors: Santos, Jean Nunes dos
Oliveira, Gabriel Queiroz Vasconcelos
Gurgel, Clarissa Araújo Silva
Souza, Renata Oliveira de
Sales, Caroline Brandi Schlaepfer
Valença Neto, Alberto de Aguiar Pires
Ramos, Eduardo Antônio Gonçalves
Keywords: Cytokeratin;Odontogenic Keratocysts;Odontogenic Neoplasms;Immunohistochemistry
Issue Date: 2009
Publisher: Springer Verlag
Abstract: Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared.
Description: Trabalho completo: acesso restrito, p.269–275
URI: http://www.repositorio.ufba.br/ri/handle/ri/6373
ISSN: 1567-2379
Appears in Collections:Artigos Publicados em Periódicos (Odontologia)

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