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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6314

Title: Effects of a single Silastic® contraceptive implant containing nomegestrol acetate (Uniplant) on endometrial morphology and ovarian function for 1 year
Other Titles: Contraception
Authors: Barbosa, Ione Cristina
Maia Junior, Hugo
Coutinho, Elsimar Metzker
Lopes, Renata
Lopes, Antônio Carlos Vieira
Noranha, Cristina
Botto, Adelmo
Keywords: Uniplant;Bleeding;Endometrium;Hysteroscopy;Contraception
Issue Date: 2006
Publisher: Contraception
Abstract: Purpose This study was undertaken to evaluate the effects of a subdermal implant containing nomegestrol acetate (Uniplant) on endometrial histology and ovarian function. Methods Twenty healthy female volunteers of reproductive age were included and completed a menstrual diary throughout the study. Hysteroscopy, transvaginal sonography and blood sampling were performed prior to implant insertion (control cycle) and following 6 and 12 months of Uniplant use. Transvaginal sonography was performed every other day from Day 8 of the cycle up to the obtainment of sonographic evidence of a 12-mm follicle, then every day until the obtainment of sonographic evidence of follicular rupture and thereafter every other day until the next menstrual bleeding. Blood samples were taken for the measurement of estradiol, follicle-stimulating hormone, luteinizing hormone and progesterone on the same days on which transvaginal sonography was performed. The implants were removed after 1 year. Results Twenty percent of cycles were ovulatory, and 80% were anovulatory. The development of persistent nonluteinized follicle occurred in 40% of all cycles studied, inadequate luteal phase occurred in 20% of cycles and no follicular development occurred in 40%. Endometrial thickness remained below 8 mm in all cycles studied. Alterations in endometrial vascularization were observed in all treated cycles. Conclusion Our results suggest that this long-acting contraceptive method affects follicular growth and endometrial vascularization, disrupts endometrial architecture and leads to inadequate luteal phase.
Description: RESTRITO
URI: http://www.repositorio.ufba.br/ri/handle/ri/6314
ISSN: 0010-7824
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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