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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6068
Tipo: Artigo de Periódico
Título: Transmission of Streptococcus pneumoniae in an urban slum community
Título(s) alternativo(s): Journal of Infection
Autor(es): Reis, Joice Neves
Palma, Tania
Ribeiro, Guilherme S.
Pinheiro, Ricardo M.
Ribeiro, Cassio Tâmara
Cordeiro, Soraia Machado
Autor(es): Reis, Joice Neves
Palma, Tania
Ribeiro, Guilherme S.
Pinheiro, Ricardo M.
Ribeiro, Cassio Tâmara
Cordeiro, Soraia Machado
Abstract: Background: Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries. Methods: We conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil.Results: Among 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae. Children <5 years of age (OR, 8.0; 95% CI, 3.5e18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2e6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotrimoxazole. BOX-PCR, PFGE and MLST analyses found that 44% of the carriage isolates belonged to 14 distinct clonal groups. Strains of the same clonal group were isolated from multiple members of 9 out of the 39 study households. Nineteen carriage isolates had genotypes that were the same as those identified among 362 strains obtained from active surveillance for meningitis.
Palavras-chave: Streptococcus pneumoniae
Nasopharyngeal carriage
Pneumococcal conjugate vaccines
Antibiotic resistance
Urban slums
URI: http://www.repositorio.ufba.br/ri/handle/ri/6068
Data do documento: 2008
Aparece nas coleções:Artigo Publicado em Periódico Nacional (ISC)

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