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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6064

Title: Immunolocalisation of laminin-1 in keratocystic odontogenic tumors
Other Titles: Acta Histochemica
Authors: Gurgel, Clarissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Melo, Leonardo de Araújo
Schlaepfer, Caroline Brandi
Souza, Renata Oliveira de
Oliveira, Márcio Campos
Santos, Jean Nunes dos
Keywords: Keratocystic odontogenic tumors;Laminin-1;Immunohistochemistry
Issue Date: Nov-2010
Publisher: Elsevier
Abstract: Keratocystic odontogenic tumors (KOTs) are distinct odontogenic lesions frequently affecting the jawbones. They may be associated with nevoid basal cell carcinoma syndrome (NBCCS), and may exhibit disorders involving the extracellular matrix. The aim of this study was to investigate the immunolocalisation of laminin-1 in 20 cases of KOTs in order to contribute to the characterization of this protein, which is little studied in odontogenic tumors. Our results showed laminin-1 in all 20 KOTs studied; its labelling intensity was weak in three cases (15%), moderate in five (25%) and strong in 12 cases (60%). Laminin-1 immunolocalisation was predominantly continuous in 18 (90%) KOTs, including areas of acanthosis, subepithelial split and epithelial buds. Weak immunolabelling was observed in regions exhibiting an inflammatory process, especially in the case of intense inflammation. These findings suggest that laminin-1 does not participate in biological processes such as cystic epithelium-cystic wall separation or the formation of epithelial islands in KOTs. Furthermore, the discontinuous and weak labelling of this protein in the basement membrane of these tumors is probably a consequence of the inflammatory process in the tumor stroma.
Description: Trabalho completo: acesso restrito,p. 624–629
URI: http://www.repositorio.ufba.br/ri/handle/ri/6064
ISSN: 0065-1281
Appears in Collections:Artigos Publicados em Periódicos (Odontologia)

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