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|Title: ||Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil|
|Other Titles: ||ACTA Tropica|
|Authors: ||Faria, Marcos Tucunduva de|
Calderwood, Michael S.
Athanazio, Daniel Abensur
McBride, Alan J.A.
Hartskeerl, Rudy A.
Pereira, Martha Maria
Ko, Albert I.
Reis, Mitermayer Galvão dos
|Keywords: ||Leptospira;Leptospirosis;Rats;Poverty areas|
|Issue Date: ||2008|
|Abstract: ||A survey was conducted to identify reservoirs for urban leptospirosis in the city of Salvador, Brazil. Sampling
protocolswere performed in the vicinity of households of severe leptospirosis cases identified during active hospital-based surveillance.Amonga total of 142 captured Rattus norvegicus (Norwegian brown rat),
80.3% had a positive culture isolate from urine or kidney specimens and 68.1% had a positive serum sample by microscopic agglutination test (MAT) titre of ≥1:100. Monoclonal antibody-based typing of isolates
identified that the agent carried by rats was Leptospira interrogans serovar Copenhageni, which was the same serovar isolated from patients during hospital-based surveillance. Leptospira spp. were not isolated from 8 captured Didelphis marsupialis (Opossum), while 5/7 had a positive MAT titre against a saprophytic
serogroup. R. rattus were not captured during the survey. The study findings indicate that the brown rat
is a major rodent reservoir for leptospirosis in this urban setting. Furthermore, the high carriage rates of
L. interrogans serovar Copenhageni in captured rats suggest that there is a significant degree of environmental
contamination with this agent in the household environment of high risk areas, which in turn is a cause of transmission during urban epidemics.|
|Description: ||Acesso restrito: Texto completo. p. 1-5|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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