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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5878

Title: Association of cytokines, neurological disability, and disease duration in HAM/TSP patients
Other Titles: Arq Neuropsiquiatr
Authors: Muniz, André Luís Nunes
Rodrigues Junior, Waldyr
Santos, Silvane Maria Braga
Jesus, Amélia Maria Ribeiro de
Porto, Maria Aurélia da Fonseca
Castro, Néviton Matos de
Oliveira Filho, Jamary
Almeida, Juliana Passos
Carvalho, Otavio Augusto Moreno de
Carvalho Filho, Edgar Marcelino de
Keywords: Human T-lymphotropic virus 1;Nervous system diseases;Cytokines;Neurological disability
Issue Date: Jun-2006
Publisher: Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange
Abstract: Objective: To identify clinical and immunological markers associated with HTLV-I associated myelopath y / tropical spastic paraparesis (HAM/TSP). Method: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame’s Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. Results: 37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. There was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-were detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers. Conclusion: This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a pro g ressive behavior of HAM/TSP. This study also shows that IFN-in PBMC supernatants are markers of HAM/TSP.
Description: p.217-221
URI: http://www.repositorio.ufba.br/ri/handle/ri/5878
ISSN: 0004-282X
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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