RI UFBA >
Escola de Nutrição >
Artigos Publicados em Periódicos (Nutrição) >
Please use this identifier to cite or link to this item:
http://repositorio.ufba.br/ri/handle/ri/5852
|
Title: | Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats |
Other Titles: | Arq Neuropsiquiatr |
Authors: | Deiró, Tereza Cristina Bomfim de Jesus Carvalho, Judelita Nascimento, Elizabeth do Medeiros, Jaiza Maria Barreto Cajuhi, Fabiana Pereira, Kelli Nogueira Ferraz Castro, Raul Manhães de |
Keywords: | Serotonin;Programming;SSRI;Citalopram;Reflex development |
Issue Date: | 2008 |
Publisher: | Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange |
Abstract: | Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats. |
Description: | p.736-740 |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5852 |
ISSN: | 0004-282X |
Appears in Collections: | Artigos Publicados em Periódicos (Nutrição)
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|