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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5852

Title: Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats
Other Titles: Arq Neuropsiquiatr
Authors: Deiró, Tereza Cristina Bomfim de Jesus
Carvalho, Judelita
Nascimento, Elizabeth do
Medeiros, Jaiza Maria Barreto
Cajuhi, Fabiana
Pereira, Kelli Nogueira Ferraz
Castro, Raul Manhães de
Keywords: Serotonin;Programming;SSRI;Citalopram;Reflex development
Issue Date: 2008
Publisher: Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange
Abstract: Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats.
Description: p.736-740
URI: http://www.repositorio.ufba.br/ri/handle/ri/5852
ISSN: 0004-282X
Appears in Collections:Artigos Publicados em Periódicos (Nutrição)

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