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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5769

Title: Comparative protein analysis of the chitin metabolic pathway in extant organisms: A complex network approach
Other Titles: BioSystems
Authors: Góes Neto, Aristóteles
Diniz, Marcelo V. C.
Santos, Leonardo B. L.
Pinho, Suani Tavares Rubim de
Miranda, José Garcia Vivas
Lobão, Thierry Corrêa Petit
Borges, Ernesto Pinheiro
El-Hani, Charbel Niño
Andrade, Roberto Fernandes Silva
Keywords: Chitin;Comparative genomics;Complex networks
Issue Date: 2010
Abstract: Chitin is a structural endogenous carbohydrate, which is a major component of fungal cell walls and arthropod exoskeletons. A renewable resource and the second most abundant polysaccharide in nature after cellulose, chitin is currently used for waste water clearing, cosmetics, medical, and veterinary applications. This work comprises data mining of protein sequences related to the chitin metabolic pathway of completely sequenced genomes of extant organisms pertaining to the three life domains, followed by meta-analysis using traditional sequence similarity comparison and complex network approaches. Complex networks involving proteins of the chitin metabolic pathway in extant organisms were constructed based on protein sequence similarity. Several usual network indices were estimated in order to obtain information on the topology of these networks, including those related to higher order neighborhood properties. Due to the assumed evolutionary character of the system, we also discuss issues related to modularity properties, with the concept of edge betweenness playing a particularly important role in our analysis. Complex network approach correctly identifies clusters of organisms that belong to phylogenetic groups without any a priori knowledge about the biological features of the investigated protein sequences. We envisage the prospect of using such a complex network approach as a high-throughput phylogenetic method.
Description: Acesso restrito: Texto completo. p. 59-66.
URI: http://www.repositorio.ufba.br/ri/handle/ri/5769
ISSN: 0303-2647
Appears in Collections:Artigos Publicados em Periódicos (Biologia)

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