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|Title: ||Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease|
|Other Titles: ||Lipids in Health and Disease|
|Authors: ||Seixas, Magda Oliveira|
Rocha, Larissa C.
Carvalho, Mauricio B.
Menezes, Joelma Figueiredo
Lyra, Isa Menezes
Nascimento, Valma M. L.
Couto, Ricardo David
Atta, Ajax Mercês
Reis, Mitermayer G.
Goncalves, Marilda S.
|Issue Date: ||2010|
|Abstract: ||Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up.We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steadystate children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, antiaggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis.
Methods: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state
infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter
respectively. Clinical data were collected from patient medical records.
Results: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol
with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant
association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005),
bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001),
aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate
dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol
(P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of
Conclusions: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype
characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers,
including those related to inflammation. This represents an important step toward a more reliable clinical
prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this
complex network of markers and their role in SCD pathogenesis.|
|Description: ||p. 1-9.|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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