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|Title: ||Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients|
|Other Titles: ||Annals of Hematology|
|Authors: ||Vilas-Boas, Wendell|
Cerqueira, Bruno A. V.
Zanette, Angela Maria Dias
Reis, Mitermayer Galvão dos
Goncalves, Marilda S.
|Keywords: ||Sickle cell anemia;Arginine . Arginase;Th17 cells;Soluble adhesion molecules;TGF-β|
|Issue Date: ||2010|
|Abstract: ||Sickle cell anemia (SCA) is characterized by a marked endothelial dysfunction, owing to many factors.Arginine metabolism can be related to the inflammatory chronic state presented by patients, playing a key role in
their clinical outcome and vascular endothelium. We investigated the serum arginase levels in 50 SCA patients
(22 men and 28 women, mean age of 17±10.5 years) and 28 healthy controls. Serum arginase levels were associated
with biochemical hemolysis markers and cytokines involved in Th17 response, as well as levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular
cell adhesion molecule-1 (sVCAM-1). Arginase concentrations were higher in SCA patients, compared with controls (p=0.005), and were significantly and positively associated with total bilirubin (p=0.004), indirect bilirubin
(p=0.04), and aspartate aminotransferase (AST; p=0.039) in the SCA patient group. Moreover, arginase was significantly and positively associated with transforming
growth factor-beta (TGF-beta; p=0.008) among SCA patients. sICAM-1 was significantly and positively associated
to reticulocytes (p=0.014) and AST (p=0.04).
sVCAM-1 was likewise associated with lactate dehydrogenase
(p=0.03). These data suggest a new insight into arginase metabolism, as we show here a shift in arginine catabolism, where TGF-beta may induces the arginase pathway instead of the nitric oxide pathway and a possible
involvement of the vascular activation and the serum arginase in chronic hemolysis among SCA patients.
Additional studies should be carried out in order to
investigate the mechanisms by which TGF-beta participates
in the metabolism of arginase in SCA patients|
|Description: ||Acesso restrito: Texto completo. p. 877-882|
|Appears in Collections:||Artigos Publicados em Periódicos (FARMACIA)|
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