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|Title: ||Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration|
|Other Titles: ||European Journal of Oral Sciences|
|Authors: ||Planello, Aline C.|
Campos, Maria Isabela Guimarães
Meloto, Carolina B.
Rizatti-Barbosa, Célia M.
Line, Sergio R. P.
Souza, Ana P. de
|Keywords: ||Genetic polymorphism;Matrix metalloproteinase;Single nucleotide polymorphism;Temporomandibular joint|
|Issue Date: ||Feb-2011|
|Abstract: ||Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain.
Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play
an important role in TMJ degeneration. We investigated the frequency of the MMP1
1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and
the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in
order to analyze the association of polymorphisms in these genes with TMJ degeneration.
The population studied comprised 117 healthy controls and 115 individuals
diagnosed with TMJ degeneration upon examination of magnetic resonance imaging
(MRI) and computed tomography (CT) images. Genotypes were determined using
PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses
revealed an association between the MMP1 2G/2G genotype and degeneration; in
contrast, there was no association between either the MMP3 or the MMP9 genotype
and degeneration. Our results may indicate a role for the MMP1 polymorphism in
|Description: ||Acesso restrito: Texto completo. p. 1-6|
|Appears in Collections:||Artigos Publicados em Periódicos (Odontologia)|
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