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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/5444
Tipo: Artigo de Periódico
Título: Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response
Título(s) alternativo(s): Transactions of the Royal Society of Tropical Medicine and Hygiene
Autor(es): Machado, Paulo Roberto Lima
Rosa, Maria Elisa Alves
Costa, Diego Luis
Mignac, Moema
Silva, João S.
Schriefer, Nicolaus Albert Borges
Teixeira, Mauro M.
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
Autor(es): Machado, Paulo Roberto Lima
Rosa, Maria Elisa Alves
Costa, Diego Luis
Mignac, Moema
Silva, João S.
Schriefer, Nicolaus Albert Borges
Teixeira, Mauro M.
Bacellar, Maria Olívia Amado Ramos
Carvalho Filho, Edgar Marcelino de
Abstract: Disseminated leishmaniasis (DL) is an emerging form of Leishmania braziliensis infection characterised by multiple cutaneous lesions on different parts of the body and a high rate of mucosal involvement. Systemic production of TNFa and IFNg in DL patients is lower than in cutaneous leishmaniasis (CL) caused by L. braziliensis, which may account for parasite dissemination due to the decreased ability to control parasite growth. In this study, the systemic and in situ immune response of DL and CL patients was characterised through evaluation of chemokine and cytokine production. In situ evaluation showed similar production of IFNg, TNFa, IL10, transforming growth factorbeta (TGFb), chemokine (CC motif) ligand 2 (CCL2), CCL3, CCL11 and chemokine (CXC motif) ligand 10 (CXCL10) in papular and ulcerative lesions from DL as well as in ulcerated lesions from CL. Serum levels of CXCL9, a chemokine that attracts Tcells, was higher in serum from DL than from CL. These data indicate that a decrease in the type 1 immune response in peripheral blood of DL patients is due to attraction of Leishmania antigenactivated Tcells to the multiple cutaneous lesions. This may account for the absence of or few parasites in the lesions and for the development of ulcers similar to those observed in CL.
Palavras-chave: Cytokines
Chemokines
Disseminated leishmaniasis
Leishmania braziliensis
Immunopathogenesis
Cutaneous leishmaniasis
URI: http://www.repositorio.ufba.br/ri/handle/ri/5444
Data do documento: 2011
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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