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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/5421

Title: Improvement of dermal burn healing by combining sodium alginate/chitosan-based films and low level laser therapy
Other Titles: Journal of Photochemistry and Photobiology B: Biology
Authors: Pinheiro, Antonio Luiz Barbosa
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Cavalcante, Danielle Rodrigues Ribeiro
Ribeiro, Maria Amalia Gonzaga
Pinheiro, Antonio Luiz Barbosa
Cardoso, Juliana Cordeiro
Barretto, Sandra Regina
Dantas, Marx Diego Meneses
Lima-Verde, Isabel Bezerra
Araújo, F. E. N.
Aciole, Gilberth Tadeu dos Santos
Melo, Cláudia Moura de
Keywords: Dressing;Polymers;Burn healing;Laser
Issue Date: 2011
Abstract: This paper aimed to evaluate the improvement of burn wounds healing by sodium alginate/chitosan-based films and laser therapy. Natural polymers with different biological activities are widely used as film dressings to improve wound healing. Lasers arrays accelerate the healing repair of soft tissue injuries. Burn procedures were performed on the backs of 60 male rats assigned into six groups: untreated (CTR), dressed with cellulose films (CL), dressed with sodium alginate/chitosan-based films (SC), laser-irradiated undressed wounds (LT), laser-irradiated wounds with cellulose (CLLT) and sodium alginate/chitosan-based films (SCLT). Laser therapy was applied for 7 days. Animals of each group were euthanised 8 and 14 days after the burn procedures. The inflammatory reaction was significantly more intense in the CTR group than in the irradiated groups after 8 and 14 days. Laser therapy stimulated myofibroblastic dif- ferentiation in 8 days, with or without dressing films. Combined laser therapy and both dressings improved epithelisation, blood vessels formation and collagenization, promoted rapid replacement of type III for type I collagen and favored the better arrangement of the newly formed collagen fibres. The combination of laser therapy and sodium alginate/chitosan-based dressing improves burn healing, apparently by modulating the epithelisation, blood vessels formation and collagenization processes.
Description: texto completo. acesso restrito. p. 51–59.
URI: http://www.repositorio.ufba.br/ri/handle/ri/5421
ISSN: 1873-2682
Appears in Collections:Artigos Publicados em Periódicos (Odontologia)

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