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|Title: ||Risk Factors for Human T Cell Lymphotropic Virus Type I among Injecting Drug Users in Northeast Brazil: Possibly Greater Efficiency of Male to Female Transmission|
|Other Titles: ||Memórias do Instituto Oswaldo Cruz|
|Authors: ||Dourado, Maria Inês Costa|
Andrade, Tarcísio Matos de
Carpenter, Catherine L.
Castro, Bernardo Galvão
|Keywords: ||human T cell lymphotropic virus type I/II (HTLV-I/II);human immunodeficiency virus type 1 (HIV-1);injecting drug use;snowball sampling;Bahia;Brazil|
|Issue Date: ||1999|
|Abstract: ||It was observed in the city of Salvador, State of Bahia, the highest seroprevalence of human T cell lymphotropic virus type 1 (HTLV-I) infection in Brazil as demonstrated by national wide blood bank surveys. In this paper, we report results of an investigation of drug use and sexual behavior associated
with HTLV-I infection among male and female injecting drug users (IDUs) in Salvador. A cross sectional study was conducted in the Historical District of Salvador from 1994-1996 (Projeto Brasil-Salvador)
and 216 asymptomatic IDUs were selected using the snowball contact technique. Blood samples were collected for serological assays. Sera were screened for human immunodeficiency virus (HIV-1/2) and HTLV-I/II antibodies by ELISA and confirmed by Western blot. The overall prevalence of HTLV-I/ II was 35.2% (76/216). The seroprevalence of HTLV-I, HTLV-II and HIV-1 was for males 22%, 11.3% and 44.1% and for females 46.2%, 10.3% and 74.4% respectively. HTLV-I was identified in 72.4% of HTLV positive IDUs. Variables which were significantly associated with HTLV-I infection among males included needle sharing practices, duration of injecting drug use, HIV-1 seropositivity and syphilis.
Among women, duration of injecting drug use and syphilis were strongly associated with HTLV-I infection. Multivariate analysis did not change the direction of these associations. Sexual intercourse might
play a more important role in HTLV-I infection among women than in men.|
|Appears in Collections:||Artigos Publicados em Periódicos Nacionais (ISC)|
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