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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/20486

Title: Frequency of celiac disease and its serological markers in patients with autoimmune hepatitis
Other Titles: Revista de Ciências Médicas e Biológicas
Authors: Franca, Rita
Bittencourt, Paulo Lisboa
Freitas, Luiz Antonio Rodrigues de
May, Daniel Simões
Andrade, Carol Ferreira de
Cunha, Liliane Monteiro
Toralles, Maria Betânia Pereira
Paraná, Raymundo
Lyra, Luiz Guilherme
Lyra, André Castro
Santos, Daniel R. Diniz
Silva, Luciana Rodrigues
Keywords: Doença celíaca;Hepatite auto-imune;Marcadores sorológicos
Issue Date: May-2007
Publisher: Instituto de Ciências da Saúde/ Universidade Federal da Bahia
Citation: FRANCA, R. et al. Frequency of celiac disease and its serological markers in patients with autoimmune hepatitis. R. Ci. méd. biol., Salvador, v. 6, n.2, p.175-182, mai./ago. 2007.
Abstract: Transglutaminase (anti-tTG) and anti-endomysial (AEA) antibodies were reported to occur in patients with autoimmune hepatitis (AIH) as well as in subjects with advanced cirrhosis, but the prevalence of celiac disease (CD) in patients with AIH is either negligible or unknown. The frequency of IgA anti-tTG and IgA AEA was determined in 64 patients (54 females, mean age 19[5-67] years ) with AIH diagnosed according to international criteria. Patients with positive or intermediate results for those antibodies were submitted to duodenal biopsy and HLA-DQ2 or DQ8 typing. Anti-tTG and AEA were detected in 6 (9%) and one patient (1.6%) with AIH, respectively. Positive and borderline results for IgA antitTG were detected, respectively, in two (3%) and four (6%) patients. Only one patient with HLA-DQ2 and IgA antitTG and IgA AEA had CD on duodenal biopsy. Two patients with either positive or borderline results for IgA anti-tTG antibody and HLA-DQ2 had normal histology on duodenal biopsy. IgA anti-tTG antibody and/or AEA were observed in 9% of AIH patients, but CD was confirmed in only one of them. The occurrence of IgA anti-tTG antibody in the other patients could be ascribed to the presence of chronic liver disease or to latent or potential CD.
URI: http://repositorio.ufba.br/ri/handle/ri/20486
ISSN: 2236-5222
Appears in Collections:Artigos Publicados em Periódicos (PPGORGSISTEM)

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