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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/19047
Tipo: Artigo de Periódico
Título: Genomic ancestry, self-rated health and its association with mortality in an admixed population: 10 year follow-up of the Bambui-Epigen (Brazil) cohort study of ageing
Título(s) alternativo(s): PLoS One
Autor(es): Costa, Maria Fernanda Furtado de Lima e
Macinko, James
Barreto, Mauricio Lima
Autor(es): Costa, Maria Fernanda Furtado de Lima e
Macinko, James
Barreto, Mauricio Lima
Abstract: Background: Self-rated health (SRH) has strong predictive value for mortality in different contexts and cultures, but there is inconsistent evidence on ethnoracial disparities in SRH in Latin America, possibly due to the complexity surrounding ethnoracial self-classification. Materials/Methods: We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual genomic proportions of African, European and Native American ancestry, and ethnoracial self-classification, with baseline and 10-year SRH trajectories in 1,311 community dwelling older Brazilians. We also examined whether genomic ancestry and eth- noracial self-classification affect the predictive value of SRH for subsequent mortality. Results: European ancestry predominated among participants, followed by African and Native American (median = 84.0%, 9.6% and 5.3%, respectively); the prevalence of Non-White (Mixed and Black) was 39.8%. Persons at higher levels of African and Native American genomic ancestry, and those self-identified as Non-White, were more likely to report poor health than other groups, even after controlling for socioeconomic conditions and an array of self reported and objective physical health measures. Increased risks for mortality associated with worse SRH trajectories were strong and remarkably similar (hazard ratio ~3) across all genomic ancestry and ethnoracial groups. Conclusions: Our results demonstrated for the first time that higher levels of African and Native American genomic ancestry and the inverse for European ancestry were strongly correlated with worse SRH in a Latin American admixed population. Both genomic ancestry and ethnoracial self-classification did not modify the strong association between baseline SRH or SRH trajectory, and subsequent mortality.
Palavras-chave: Mortality
Genomic
Ethno-racial groups
País: Brasil
Editora / Evento / Instituição: Public Library of Science
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/19047
Data do documento: 2015
Aparece nas coleções:Artigo Publicado em Periódico Estrangeiro (ISC)

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