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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/17078
Tipo: Artigo de Periódico
Título: Estimation of Biodiesel Cytotoxicity by Using Acid Phosphatase as a Biomarker of Lysosomal Integrity
Título(s) alternativo(s): Bulletin of Environmental Contamination and Toxicology
Autor(es): Cruz, Andréa Cristina Santos da
Leite, Maria Bernadete Neiva Lemos
Rodrigues, Luiz Erlon Araújo
Nascimento, Iracema Andrade
Autor(es): Cruz, Andréa Cristina Santos da
Leite, Maria Bernadete Neiva Lemos
Rodrigues, Luiz Erlon Araújo
Nascimento, Iracema Andrade
Abstract: Biodiesel is promoted as environmentally less harmful than diesel fuel. Nevertheless its water-soluble-fraction (WSF) may contain methanol, which appears by a reversion of the transesterification reaction, when biodiesel contacts water. This paper evaluated the loss of the lysosomal membrane integrity in liver homogenate of juvenils Tilapia exposed to biodiesels-WSF, through the increase of the acid phosphatase activity, as an evidence of citotoxicity. Differences in the enzyme activity levels (3.4, 2.3 and 0.8 mU mg−1 total protein over the control value, which was 1.6 mU mg−1 total protein), found for castor oil, waste cooking-oil and palm oil-biodiesels, respectively, were indicative of their toxicity according to this decreasing trend. WSF-chromatograms suggest the cytotoxicity as related to methanol.
Palavras-chave: Biodiesel
Hepatotoxicity
Lysosomal biomarker
Acid phosphatase
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/17078
Data do documento: 2012
Aparece nas coleções:Artigo Publicado em Periódico (LABIOMAR)

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