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|Title: ||Antibodies to schistosoma mansoni in human cerebrospinal fluid|
|Other Titles: ||American Journal of Tropical Medicine and Hygiene|
|Authors: ||Lemaire, Denise Carneiro|
Santos, Isis F. Magalhães
Andrade Filho, Antônio de Souza
Queiroz, Aristides Cheto de
Carvalho, Otavio Augusto Moreno de
Carmo, Theomira Mauadie Azevedo
Siqueira, Isadora C.
Andrade, Débora M.
Rego, Michely F.
Guedes, Ana Paula T.
Reis, Mitermayer Galvão dos
|Keywords: ||Schistosoma mansoni;Immunoglobulin Isotypes;Neuroschistosomiasis|
|Issue Date: ||2003|
|Abstract: ||Cerebrospinal fluid (CSF) and serum samples from patients suspected of having neuroschistosomiasis (NS)
were evaluated by an enzyme-linked immunosorbent assay. Monoclonal antibodies of various immunoglobulin isotypes
(IgM, IgA, IgE, total IgG, IgG1, IgG2, IgG3, and IgG4) were used to detect antibodies against Schistosoma mansoni
soluble egg antigen (SEA) and soluble worm adult preparation (SWAP). Of the 83 CSF samples tested, 55% were
reactive toSEA (26% were reactive only toSEA and 29% tobo th SEA and SWAP), 34% were reactive toSWAP (5%
only to SWAP and 29% to both SEA and SWAP), and 40% were not reactive with any antigen. Cases that tested
positive for SWAP in CSF and negative in serum were not found. Samples with high specific IgG antibody titers were
selected for immunoglobulin isotype profiling. In the CSF samples, the antibodies against SEA and SWAP were mainly
IgM, IgG1, and IgG4, although other immunoglobulins were also detected. Interestingly, nine patients had high levels
of IgG1 only in the CSF. These results suggest that there is local synthesis of IgG1, and that this isotype could be an
important immunologic marker in the diagnosis of NS.|
|Description: ||Texto completo: acesso restrito. p. 294-298|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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