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|Title: ||Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts|
|Other Titles: ||Journal of Molecular Histology|
|Authors: ||Santos, Luciano Cincurá Silva|
Ramos, Eduardo Antônio Gonçalves
Gurgel, Clarissa Araújo Silva
Santana, Edmar José Borges de
Santos, Jean Nunes dos
|Keywords: ||Radicular cyst;Dental granuloma;Immunohistochemistry;Langerhans cell|
|Issue Date: ||2007|
|Abstract: ||Objective: Dental granulomas (DGs) and radicular cysts (RCs) are chronic periapical lesions frequently involving the jaws. Langerhans cells (LCs) are dendritic cells responsible for the presentation of antigens to T lymphocytes. This study examined the expression of LCs in DG and RCs by immunohistochemical staining.
Study Design: Eighteen cases of DGs and 26 cases of RCs were analyzed using anti-CD1a marker.
Results: CD1a-labeled LCs were observed in 11.1% of DGs and in 69.2% of RCs, showing a significant correlation (P < 0.0001; Fisher’s test). In DGs, LCs were only observed in granulation tissue, showing discrete immunostaining density. In RCs, LCs exhibited both a round and a dendritic shape in all epithelial layers. Although a correlation was observed between immunostaining density and epithelial thickness, as well as between immunostaining and inflammatory intensity, the differences were not significant in radicular cysts.
Conclusion: Langerhans cells provide important insight into the immunopathogenesis of chronic periapical lesions.|
|Description: ||Texto completo: acesso restrito. p. 201-205|
|Appears in Collections:||Artigos Publicados em Periódicos (Odontologia)|
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