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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15949

Title: Clinical manifestations associated with HTLV type I infection: a cross-sectional study
Other Titles: AIDS Research and Human Retroviruses
Authors: Caskey, Marina F.
Morgan, Daniel J.
Porto, Maria Aurélia da Fonseca
Giozza, Silvana P.
Muniz, André Luís Nunes
Orge, Glória O.
Travassos, Maria J.
Barrón, Yolanda
Carvalho Filho, Edgar Marcelino de
Glesby, Marshall J.
Issue Date: 2007
Abstract: Human T-lymphotropic virus type I (HTLV-I) causes HTLV-I-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia in a small percentage of infected individuals. HTLV-I infection is increasingly associated with clinical manifestations. To determine the prevalence of clinical manifestations in HTLV-I infected individuals, we conducted a cross-sectional study of 115 HTLV-I-infected blood donors without myelopathy and 115 age- and sex-matched seronegative controls. Subjects answered a standardized questionnaire and underwent physical examination. Compared with controls, HTLV-I-infected subjects were more likely to report arm or leg weakness (OR = 3.8, 95% CI: 1.4–10.2; OR = 4.0, 95% CI: 1.6–9.8, respectively), hand or foot numbness (OR = 2.1, 95% CI: 1.1–3.9; OR = 4.8, 95% CI: 2.0–11.7, respectively), arthralgia (OR = 3.3, 95% CI: 1.7–6.4), nocturia (OR = 2.7, 95% CI: 1.04–6.8), erectile dysfunction (OR = 4.0, 95% CI: 1.6–9.8), and to have gingivitis (OR = 3.8, 95% CI: 1.8–7.9), periodontitis (OR = 10.0, 95% CI: 2.3–42.8), and dry oral mucosa (OR = 7.5, 95% CI: 1.7–32.8). HTLV-I infection is associated with a variety of clinical manifestations, which may occur in patients who have not developed myelopathy.
Description: Texto completo: acesso restrito. p. 365-371
URI: http://repositorio.ufba.br/ri/handle/ri/15949
ISSN: 0889-2229
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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