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|Title: ||Clinical manifestations associated with HTLV type I infection: a cross-sectional study|
|Other Titles: ||AIDS Research and Human Retroviruses|
|Authors: ||Caskey, Marina F.|
Morgan, Daniel J.
Porto, Maria Aurélia da Fonseca
Giozza, Silvana P.
Muniz, André Luís Nunes
Orge, Glória O.
Travassos, Maria J.
Carvalho Filho, Edgar Marcelino de
Glesby, Marshall J.
|Issue Date: ||2007|
|Abstract: ||Human T-lymphotropic virus type I (HTLV-I) causes HTLV-I-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia in a small percentage of infected individuals. HTLV-I infection is increasingly associated with clinical manifestations. To determine the prevalence of clinical manifestations in HTLV-I infected individuals, we conducted a cross-sectional study of 115 HTLV-I-infected blood donors without myelopathy and 115 age- and sex-matched seronegative controls. Subjects answered a standardized questionnaire and underwent physical examination. Compared with controls, HTLV-I-infected subjects were more likely to report arm or leg weakness (OR = 3.8, 95% CI: 1.4–10.2; OR = 4.0, 95% CI: 1.6–9.8, respectively), hand or foot numbness (OR = 2.1, 95% CI: 1.1–3.9; OR = 4.8, 95% CI: 2.0–11.7, respectively), arthralgia (OR = 3.3, 95% CI: 1.7–6.4), nocturia (OR = 2.7, 95% CI: 1.04–6.8), erectile dysfunction (OR = 4.0, 95% CI: 1.6–9.8), and to have gingivitis (OR = 3.8, 95% CI: 1.8–7.9), periodontitis (OR = 10.0, 95% CI: 2.3–42.8), and dry oral mucosa (OR = 7.5, 95% CI: 1.7–32.8). HTLV-I infection is associated with a variety of clinical manifestations, which may occur in patients who have not developed myelopathy.|
|Description: ||Texto completo: acesso restrito. p. 365-371|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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