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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15445

Title: A naturalistic, 9-month follow-up, comparing olanzapine and conventional antipsychotics on sexual function and hormonal profile for males with schizophrenia
Other Titles: Journal of Psychopharmacology
Authors: Costa, Anna Maria Niccolai
Lima, Mauricio Silva de
Faria, Marité
Rodrigues Filho, Salomão
Oliveira, Irismar Reis De
Mari, Jair de Jesus
Keywords: Schizophrenia;Sexual dysfunction;Hormones;Prolactin;Olanzapine;Antipsychotics
Issue Date: 2007
Abstract: Second generation antipsychotics have less influence on prolactin levels than conventional antipsychotics (CA), which are commonly associated with sexual dysfunction and hyperprolactinaemia. However, only a few studies have been conducted assessing these newer antipsychotics and sexual function/dysfunction. The aim of this study is to evaluate the sexual function and hormonal profile of male schizophrenic patients taking olanzapine or CA. Sixty-three inpatients with acute episodes of schizophrenia were randomly assigned to take either olanzapine, or go on conventional antipsychotic treatment. The Dickson-Glazer sexual functioning questionnaire was used to assess sexual functioning where serum prolactin, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, and sex hormone-binding globulin concentrations were measured. All measurements were taken on discharge from the inpatient unit (baseline), and again at 3 and 9 months after discharge. Prolactin levels in the olanzapine group decreased more rapidly and were significantly lower than in the CA group after 3 months (12.1±6.3µg/l, p=0.01; 18.1±11.2µg/l, p=0.564, respectively). After nine months, there was a tendency toward normal levels in both groups, and the frequency of sexual complaints did not differ between the groups. This study showed no difference between olanzapine and conventional antipsychotics regarding sexual complaints in the treatment of schizophrenia, but did show a difference in the hormone level normalization rate.
Description: Texto completo: acesso restrito. p. 165-170.
URI: http://repositorio.ufba.br/ri/handle/ri/15445
ISSN: 0269-8811
Appears in Collections:Artigos Publicados em Periódicos (PSI)

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