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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15138

Title: Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of Melan A and HMB45 positivity in the cystic epithelial lining
Other Titles: Annals of Diagnostic Pathology
Authors: Athanazio, Paulo Roberto Fontes
Pereira Filho, José do Egypto
Amorim, Daniele Meneses de
Sweet, Gloria Maria Maranhão
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
Keywords: Angiomyolipoma;Kidney;Perivascular epithelioid cell neoplasms;Immunohistochemistry;Kidney neoplasms
Issue Date: 2012
Abstract: Renal angiomyolipoma (AML) may present as rare variants such as epithelioid and AML with epithelial cysts posing difficulties for the diagnosis to the surgical pathologist. We report a case of a 46-year-old male patient presenting a 5-cm solid tumor in the lower pole of the left kidney, with cystic changes at cut surface. The tumor exhibited 95% of epithelioid cells with atypical nuclei. A small focus of typical AML was observed. The immunoprofile of tumor cells was classical of AML including expression of melanocytic markers such as HMB45 and Melan A. We report the immunohistochemical study of the cystic component in an epithelioid AML. In contrast to the immunoreactivity reported in typical AML, the present case shows obvious expression of melanocytic markers in the cystic epithelial lining. This is strong evidence that these cysts are neoplastic and derived from AML, rather than entrapped native collecting duct epithelium.
Description: Texto completo: acesso restrito. p. 397–401
URI: http://repositorio.ufba.br/ri/handle/ri/15138
ISSN: 1092-9134
Appears in Collections:Artigos Publicados em Periódicos (ICS)

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