https://repositorio.ufba.br/handle/ri/15138
Tipo: | Artigo de Periódico |
Título: | Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of Melan A and HMB45 positivity in the cystic epithelial lining |
Título(s) alternativo(s): | Annals of Diagnostic Pathology |
Autor(es): | Athanazio, Paulo Roberto Fontes Pereira Filho, José do Egypto Amorim, Daniele Meneses de Sweet, Gloria Maria Maranhão Freitas, Luiz Antonio Rodrigues de Athanazio, Daniel Abensur |
Autor(es): | Athanazio, Paulo Roberto Fontes Pereira Filho, José do Egypto Amorim, Daniele Meneses de Sweet, Gloria Maria Maranhão Freitas, Luiz Antonio Rodrigues de Athanazio, Daniel Abensur |
Abstract: | Renal angiomyolipoma (AML) may present as rare variants such as epithelioid and AML with epithelial cysts posing difficulties for the diagnosis to the surgical pathologist. We report a case of a 46-year-old male patient presenting a 5-cm solid tumor in the lower pole of the left kidney, with cystic changes at cut surface. The tumor exhibited 95% of epithelioid cells with atypical nuclei. A small focus of typical AML was observed. The immunoprofile of tumor cells was classical of AML including expression of melanocytic markers such as HMB45 and Melan A. We report the immunohistochemical study of the cystic component in an epithelioid AML. In contrast to the immunoreactivity reported in typical AML, the present case shows obvious expression of melanocytic markers in the cystic epithelial lining. This is strong evidence that these cysts are neoplastic and derived from AML, rather than entrapped native collecting duct epithelium. |
Palavras-chave: | Angiomyolipoma Kidney Perivascular epithelioid cell neoplasms Immunohistochemistry Kidney neoplasms |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15138 |
Data do documento: | 2012 |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
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