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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14986

Title: A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats
Other Titles: Lipids
Authors: Deiró, Tereza Cristina Bomfim de Jesus
Leandro, Carol Góis
Oliveira, Tchana Weyll Souza
Perez, Gabriela dos Santos
Silva, Darlene da França
Druzian, Janice Izabel
Couto, Ricardo David
Medeiros, Jairza Maria Barreto
Keywords: Hyperlipidic diet;Cholesterolemia;Rats;Developmental plasticity;Critical period of development
Issue Date: 2011
Abstract: The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation (C p, n = 10; pups from control mothers; and HLp n = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HLp group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.
Description: Texto completo: acesso restrito. p. 1071-1074
URI: http://repositorio.ufba.br/ri/handle/ri/14986
ISSN: 0024-4201
Appears in Collections:Artigos Publicados em Periódicos (Nutrição)

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