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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14777

Title: Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations
Other Titles: Analytical Methods
Authors: Teixeira, Leonardo Sena Gomes
Teixeira, Maiana de Araujo
Bueno, Admar Jorge Machado
Brito, Cristiane F. de
Dantas, Alailson Falcão
Costa, Antonio Celso Spinola
Issue Date: 2011
Abstract: Three nitroanilines (2-methoxy-4-nitroaniline, 2,4-dinitroaniline and 2-methyl-4-nitroaniline) were tested as spectrophotometric reagents for determination of ethinylestradiol (ETE). The determinations were based on absorbance measurments of the reaction product obtained from the coupling of each diazotized nitroaniline with ETE. Optimization of temperature, pH and diazotization coupling reaction time was realized. 2-Methyl-4-nitroaniline provided the more sensitive system for ETE spectrophotometric determination at 531 nm and the analytical response was linear in the concentration range of 0.65–10.0 µg ml−1. The limit of detection and coefficient of variation were estimated as 197 µg l−1 and 4.5%, respectively. The results showed that the proposed method is simple and rapid, allowing selective determination of analyte. The method successfully determined ETE in oral contraceptive formulations.
Description: p. 1198–1201
URI: http://repositorio.ufba.br/ri/handle/ri/14777
ISSN: 1759-9660
Appears in Collections:Artigos Publicados em Periódicos (Quimica)

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