DSpace

RI UFBA >
Instituto de Saúde Coletiva - ISC >
Artigos Publicados em Periódicos Estrangeiros (ISC) >

Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14717

Title: Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil
Other Titles: JAIDS Journal of Acquired Immune Deficiency Syndromes
Authors: Dourado, Maria Inês Costa
Bermúdez-Aza, Elkin Hernan
Kerr, Ligia Regina Franco Sansigolo
Kendall, Carl Kendall
Pinho, Adriana Araujo
Mello, Maeve Brito de
Mota, Rosa Maria Salani
Guimarães, Mark Drew Crosland
Alencar, Cecilia Salete
Keywords: HIV-1;Men who have sex with men,;Respondent-driven sampling,;Brazil;Antiretroviral resistance
Issue Date: 2011
Abstract: Background: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil. Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naïve (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines. Results: The most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). The overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). The prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). The most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases). Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic.
Description: Texto completo: acesso restrito. p. 186-192
URI: http://repositorio.ufba.br/ri/handle/ri/14717
ISSN: 1525-4135
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

Files in This Item:

File Description SizeFormat
Ines Dourado.pdf252.51 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

    Universidade Federal da Bahia

Contate-nos. Saiba mais sobre o RI/UFBA