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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14390

Title: Prevalence of hepatopulmonary syndrome in patients with decompensated chronic liver disease and its impact on short-term survival
Other Titles: Arquivos de Gastroenterologia
Authors: Ferreira, Palmireno Pinheiro
Câmara, Edmundo José Nassri
Paula, Rogério Luis Porto de
Zollinger, Cláudio Celestino
Cavalcanti, Andréa Ribeiro
Bittencourt, Paulo Lisboa
Keywords: Hepatopulmonary syndrome;Liver diseases;Chronic disease;Inpatients
Issue Date: 2008
Abstract: BACKGROUND: Hepatopulmonary syndrome is reported to occur in 4% to 32% of the patients with chronic liver disease and is associated with poor liver function and shortened patient survival before and after liver transplantation. AIMS: To assess the frequency of hepatopulmonary syndrome in Brazilian patients with decompensated chronic liver disease and to investigate its impact on patient survival. METHODS: One hundred and thirty patients (101 males, mean age 61 ± 12 years) with decompensated chronic liver disease were evaluated for the presence of hepatopulmonary syndrome. The diagnosis of hepatopulmonary syndrome was considered in the presence of alveolar arterial oxygen gradient of more than 15 mm Hg and of pulmonary vascular dilatation assessed by contrast enhanced echocardiography. RESULTS: Hepatopulmonary syndrome was observed in 21 (16%) patients. The presence of hepatopulmonary syndrome was significantly associated with severity of liver disease assessed by the MELD (Model for End-Stage Liver Disease) score, but not with in hospital mortality after admission due to decompensated chronic liver disease. CONCLUSIONS: Hepatopulmonary syndrome occurs in 16% of patients with chronic liver disease and is associated with disease severity according to the MELD score. Short term mortality following decompensation of chronic liver disease was not associated with hepatopulmonary syndrome.
Description: Texto completo: acesso restrito. p. 34-37
URI: http://repositorio.ufba.br/ri/handle/ri/14390
ISSN: 0004-2803
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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