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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14280

Title: Majority of Interferon-g–Producing CD4+ Cells in Patients Infected with Human T Cell Lymphotrophic Virus Do Not Express Tax Protein
Other Titles: Journal of Infectious Diseases
Authors: Carvalho Filho, Edgar Marcelino de
Mitre, Edward
Thompson, Robert W.
Nutman, Thomas B.
Neva, Franklin A.
Keywords: Human T Cell Lymphotrophic Virus;Gene Products, tax;CD4 + Cells;Human T-lymphotropic virus 1
Issue Date: 2003
Abstract: The present study was conducted to determine whether interferon (IFN)-γ production by CD4+ cells in patients infected with human T cell lymphotropic virus (HTLV) is associated with expression of Tax, an HTLV type 1 (HTLV-1) transactivator. The frequency of IFN-γ production from CD4+ cells was greater in HTLV-1-infected patients (n = 21) than in uninfected (n = 3) and Strongyloides stercoralis-infected patients (n = 4), and greater in patients with HTLV-1 with detectable Tax than in patients with HTLV-1 with undetectable Tax. In the patients with HTLV-1 with detectable Tax, the majority of CD4+ cells making IFN-γ did not express Tax.
Description: Texto completo: acesso restrito. p. 428-432
URI: http://repositorio.ufba.br/ri/handle/ri/14280
ISSN: 0022-1899
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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