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|Title: ||Majority of Interferon-g–Producing CD4+ Cells in Patients Infected with Human T Cell Lymphotrophic Virus Do Not Express Tax Protein|
|Other Titles: ||Journal of Infectious Diseases|
|Authors: ||Carvalho Filho, Edgar Marcelino de|
Thompson, Robert W.
Nutman, Thomas B.
Neva, Franklin A.
|Keywords: ||Human T Cell Lymphotrophic Virus;Gene Products, tax;CD4 + Cells;Human T-lymphotropic virus 1|
|Issue Date: ||2003|
|Abstract: ||The present study was conducted to determine whether interferon (IFN)-γ production by CD4+ cells in patients infected with human T cell lymphotropic virus (HTLV) is associated with expression of Tax, an HTLV type 1 (HTLV-1) transactivator. The frequency of IFN-γ production from CD4+ cells was greater in HTLV-1-infected patients (n = 21) than in uninfected (n = 3) and Strongyloides stercoralis-infected patients (n = 4), and greater in patients with HTLV-1 with detectable Tax than in patients with HTLV-1 with undetectable Tax. In the patients with HTLV-1 with detectable Tax, the majority of CD4+ cells making IFN-γ did not express Tax.|
|Description: ||Texto completo: acesso restrito. p. 428-432|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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