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Title: Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil
Other Titles: Trans. R. Soc. Trop. Med. Hyg
Authors: Cordeiro, Soraia Machado
Neves, Alan B.
Ribeiro, Cássio T.
Petersen, Maya L.
Gouveia, Edilane L.
Ribeiro, Guilherme S., et al.
Keywords: Meningococcal Disease;Meningitis;Neisseria;Meningitidis;Serogroup;Epidemiology;Brazil
Issue Date: 2007
Publisher: Royal Society of Tropical Medicine and Hygiene Transactions
Abstract: This study aimed to describe the clinical, epidemiological and microbiological features of meningococcal meningitis in Salvador, Brazil. Between February 1996 and January 2001, a hospital based surveillance prospectively identified cases of culture-positive meningococcal meningitis. Demographic and clinical data were collected through interview and medical chart review. Antisera and monoclonal antibodies were used to determine the serogroup and serotype: serosubtype of the isolates, respectively. Surveillance identified a total of 408 cases of meningococcal meningitis, with a case fatality rate of 8% (32/397). The mean annual incidence for the 304 culture-positive cases residing in metropolitan Salvador was 1.71 cases per 100 000 population. Infants <1 year old presented the highest incidence (14.7 cases per 100 000 population). Of the 377 serogrouped isolates, 82%, 16%, 2% and 0.3% were serogroups B, C, W135 and Y, respectively. A single serotype:serosubtype (4,7:P1.19,15) accounted for 64% of all cases. Continued surveillance is necessary to characterise strains and to define future prevention and control strategies.
URI: http://repositorio.ufba.br/ri/handle/ri/14006
ISSN: 0035-9203
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

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