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|Title: ||Hospital-based surveillance of meningococcal meningitis in Salvador, Brazil|
|Other Titles: ||Trans. R. Soc. Trop. Med. Hyg|
|Authors: ||Cordeiro, Soraia Machado|
Neves, Alan B.
Ribeiro, Cássio T.
Petersen, Maya L.
Gouveia, Edilane L.
Ribeiro, Guilherme S., et al.
|Keywords: ||Meningococcal Disease;Meningitis;Neisseria;Meningitidis;Serogroup;Epidemiology;Brazil|
|Issue Date: ||2007|
|Publisher: ||Royal Society of Tropical Medicine and Hygiene Transactions|
|Abstract: ||This study aimed to describe the clinical, epidemiological and microbiological features
of meningococcal meningitis in Salvador, Brazil. Between February 1996 and January
2001, a hospital based surveillance prospectively identified cases of culture-positive meningococcal meningitis. Demographic and clinical data were collected through interview and medical chart review. Antisera and monoclonal antibodies were used to determine the serogroup and serotype: serosubtype of the isolates, respectively. Surveillance identified a total of 408 cases of meningococcal meningitis, with a case fatality rate of 8% (32/397). The mean annual incidence for the 304 culture-positive cases residing in metropolitan Salvador was 1.71 cases per 100 000
population. Infants <1 year old presented the highest incidence (14.7 cases per 100 000 population). Of the 377 serogrouped isolates, 82%, 16%, 2% and 0.3% were serogroups B, C, W135 and Y, respectively. A single serotype:serosubtype (4,7:P1.19,15) accounted for 64% of all cases. Continued surveillance is necessary to characterise strains and to define future prevention and
|Appears in Collections:||Artigos Publicados em Periódicos Estrangeiros (ISC)|
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