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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13912
Tipo: Artigo de Periódico
Título: Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin
Título(s) alternativo(s): Journal of Medical Virology
Autor(es): Mello, Vivianne Barretto de
Cruz, Thomaz Rodrigues Porto da
Nuñez, Geila Ribeiro
Simões, Maria Tereza
Braga, Hélio Jose Vieira
Araújo, César
Cunha, Simone Muniz Carvalho Fernandes da
Schinoni, Maria Isabel
Cruz, Marla
Paraná, Raymundo
Autor(es): Mello, Vivianne Barretto de
Cruz, Thomaz Rodrigues Porto da
Nuñez, Geila Ribeiro
Simões, Maria Tereza
Braga, Hélio Jose Vieira
Araújo, César
Cunha, Simone Muniz Carvalho Fernandes da
Schinoni, Maria Isabel
Cruz, Marla
Paraná, Raymundo
Abstract: Patients with hepatitis C virus (HCV) infection present higher risk of developing type-2 diabetes mellitus (DM). However, the mechanism of this association and the role of antiviral treatment are still unclear. The objective of this study was to investigate the relationship between the use of peguilated interferon and the development of insulin resistance (IR) in these patients. Methods: HOMA index was evaluated in 30 HCV-infected patients just before and during the first 6 months of treatment with peguilated interferon plus ribavirin. Anthropometrical parameters and glucose/cholesterol profile were also monitored. Results: No changes in HOMA after 6 months of treatment were observed. Glucose levels decreased but not significantly (P = 0.059). Patients with higher HOMA index after 6 months of treatment also presented higher aminotransferase levels (P = 0.03), higher fat index on computed tomography (P = 0.011), longer time of exposure to the virus (P = 0.021), and a positive smoking history when compared to non-insulin resistant patients (P = 0.045). There was no influence of fibrosis stage on liver biopsy in the insulin-resistance development. Conclusions: No changes in the IR were observed after 6 months of treatment. Insulin resistance is related to the abdominal fat and anthropometrical parameters rather than to the antiviral treatment. J. Med.
Palavras-chave: Interferon
Peripheral insulin resistance
Virus c hepatitis
Diabetes mellitus
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13912
Data do documento: 2006
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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