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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/13897

Title: Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis
Other Titles: Pancreas
Authors: Bendicho, Maria Teresita Del Niño Jesus Fernandez
Guedes, Jorge Carvalho
Silva, Naize Nara Pinheiro da
Santana, Genoile Oliveira
Santos, Raquel Rocha dos
Lyra, André Castro
Lyra, Luiz Guilherme Costa
Nascimento, Roberto José Meyer
Lemaire, Denise Carneiro
Keywords: Chronic;Pancreatitis;Cytokines;Genetic polymorphism;Transforming growth factor-b1
Issue Date: 2005
Abstract: Objectives: The polymorphisms in cytokine genes have allowed for the understanding of the genetic determinants of diseases. The aims of this study were to describe and compare the frequencies of polymorphisms on the interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-[alpha], transforming growth factor (TGF)-[beta]1, and interferon (IFN)-[gamma] genes between patients with chronic pancreatitis (CP) and healthy individuals from Bahia, Brazil. Methods: Twenty-eight individuals were evaluated at a university gastroenterology outpatient service (4 women and 24 men), all diagnosed with CP based on clinical and radiologic aspects. The control group was composed of 94 (11 women and 83 men) blood donors. The polymorphisms studied were TNF-[alpha] (-308G/A), TGF-[beta]1 (codon 10C/T, codon 25C/G), IL-10 (-1082A/G; -819T/C; -592A/C), IL-6 (-174G/C), and IFN-[gamma] (+874T/A). Results: A statistically significant difference was observed in the frequency of the polymorphisms between the group of patients with CP and the group of healthy individuals with the polymorphism of the TGF-[beta]1 gene on codon 10. No statistically significant differences were found for the allele and genotypic frequencies on the genes that code TNF-[alpha], IFN-[gamma], IL-10, and TGF-[beta]1 codon 25, and IL-6 between the control and case groups. Conclusion: The genotypes corresponding to the high TGF-[beta]1 producer phenotypes can be associated with the fibrogenesis shown with CP.
Description: Texto completo: acesso restrito. p. 333-336
URI: http://repositorio.ufba.br/ri/handle/ri/13897
ISSN: 0885-3177
Appears in Collections:Artigos Publicados em Periódicos (ICS)

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