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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13636
Tipo: Artigo de Periódico
Título: Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
Título(s) alternativo(s): Phytomedicine
Autor(es): Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
Autor(es): Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
Abstract: This in vitro study evaluated the antimicrobial activity of extracts obtained from Rheedia brasiliensis fruit (bacupari) and its bioactive compound against Streptococcus mutans. Hexane, ethyl-acetate and ethanolic extracts obtained (concentrations ranging from 6.25 to 800 μg/ml) were tested against S. mutans UA159 through MIC/MBC assays. S. mutans 5-days-old biofilms were treated with the active extracts (100×MIC) for 0, 1, 2, 3 and 4 h (time-kill) and plated for colony counting (CFU/ml). Active extracts were submitted to exploratory chemical analyses so as to isolate and identify the bioactive compound using spectroscopic methods. The bioactive compound (concentrations ranging from 0.625 to 80 μg/ml) was then tested through MIC/MBC assays. Peel and seed hexane extracts showed antimicrobial activity against planktonic cells at low concentrations and were thus selected for the time kill test. These hexane extracts reduced S. mutans biofilm viability after 4 h, certifying of the bioactive compound presence. The bioactive compound identified was the polyprenylated benzophenone 7-epiclusianone, which showed a good antimicrobial activity at low concentrations (MIC: 1.25–2.5 μg/ml; MBC: 10–20 μg/ml). The results indicated that 7-epiclusianone may be used as a new agent to control S. mutans biofilms; however, more studies are needed to further elucidate the mechanisms of action and the anticariogenic potential of such compound found in R. brasiliensis.
Palavras-chave: Rheedia brasiliensis
Antimicrobial activity
7-Epiclusianone
Streptococcus mutans
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13636
Data do documento: 2008
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Odontologia)

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