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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/13533

Title: Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes
Other Titles: Journal of Medical Microbiology
Authors: Santos, Cleiton S.
Macedo, Júlio O.
Bandeira, Maurício de Sousa
Chagas Júnior, Adenizar Delgado das
McBride, Alan John Alexander
McBride, Flavia Weykamp da Cruz
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
Issue Date: 2010
Abstract: The mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. Some studies on transgenic and/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wild-type mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were susceptible to lethal leptospirosis. However, these strains developed specific pathologies associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions, whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis.
Description: Texto completo: acesso restrito. p.1101-1106
URI: http://repositorio.ufba.br/ri/handle/ri/13533
ISSN: 0022-2615
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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