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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/13501

Title: Chagas disease is independently associated with brain atrophy
Other Titles: Journal of Neurology
Authors: Oliveira Filho, Jamary
Melo, Rodrigo Morel Vieira de
Reis, Paulo S. O.
Lacerda, Amanda M.
Neville, Iuri S.
Cincura, Carolina
Menezes, Daniela F.
Viana, Leila Castro
Jesus, Pedro A. P.
Lopes, Antonio Alberto da Silva
Reis, Francisco J. F. B.
Furie, Karen L.
Keywords: Other cerebrovascular disease/stroke;All cognitive disorders/dementia;Computed tomography;Parasitic infections
Issue Date: 2009
Abstract: Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain involvement in CD has been attributed to left ventricular dysfunction, resulting in chronic brain ischemia due to hypoperfusion and/or embolic infarcts. However, cognitive impairment in CD may occur independently of cardiac disease. Therefore, we aimed to investigate head computed tomography (CT) findings in patients with Chagas disease cardiomyopathy (CDC) in comparison with other cardiomyopathies (OC). We studied 73 patients with CDC (n = 41) or OC (n = 32) matched for age and gender. These patients underwent head CT, rated by an investigator blinded to all clinical information. Head CT was rated for the presence of lacunar or territorial infarcts, as well as for measuring the total volumes of the brain, cerebellum and ventricles. Total brain volume was smaller in CDC as compared to OC patients (1,135 ± 150 vs. 1,332 ± 198 cm3, P < 0.001). Cerebellar and ventricular volumes did not differ between the groups. The prevalence of brain infarcts did not differ significantly between the groups. Chagas disease was the only independent predictor of brain atrophy in the multivariable analysis (OR = 1.38; 95% CI = 1.06–1.79, P = 0.017). Chagas disease is associated with brain atrophy independent of structural cardiac disease related to cardiomyopathy. Brain atrophy, rather than multiple infarcts, may represent the main anatomical substrate of cognitive impairment in Chagas disease.
Description: Texto completo: acesso restrito. p. 1363-1365
URI: http://repositorio.ufba.br/ri/handle/ri/13501
ISSN: 0340-5354
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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