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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/12451

Title: Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil
Other Titles: Clinical Infectious Diseases
Authors: Ko, Albert I.
Reis, Joice Neves
Coppola, Steven J.
Gouveia, Edilane Lins
Cordeiro, Soraia Machado
Lôbo, Tatiana Silva
Pinheiro, Ricardo M.
Salgado, Kátia
Dourado, Cibele M. Ribeiro
Tavares-Neto, José
Rocha, Heonir
Reis, Mitermayer Galvão
Johnson Jr, Warren D.
Riley, Lee W.
Keywords: Streptococcus pneumoniae;Meningitis
Issue Date: 2000
Publisher: Clinical Infectious Diseases
Abstract: Active hospital-based surveillance in the city of Salvador, Brazil, from December 1995 through October 1998, identified 221 patients with confirmed pneumococcal meningitis. Of these 221 patients, 29 (13%) had isolates with intermediate-level resistance to penicillin. Infection with these penicillin-nonsusceptible isolates was significantly associated with age of !2 years (P ! .0019), previous antibiotic use (P ! .0006), and coresistance to trimethoprimsulfamethoxazole (P ! .0000). Serotype 14 was the most prevalent serotype (55.2%) of penicillin- nonsusceptible isolates. Strain typing by repetitive element BOX polymerase chain reaction (PCR) analysis showed that penicillin-nonsusceptible serotype 14 isolates had closely related BOX PCR patterns, whereas penicillin-susceptible serotype 14 isolates each had distinct, unrelated patterns. Penicillin-nonsusceptible serotype 14 isolates from Salvador and other Brazilian cities had similar BOX PCR patterns. These observations indicate that in Brazil a large proportion of cases of penicillin-nonsusceptible pneumococcal meningitis appear to be caused by a closely related group of serotype 14 strains that may have disseminated to widely separate geographic areas.
Description: Texto completo. Acesso restrito. p. 78-86
URI: http://www.repositorio.ufba.br/ri/handle/ri/12451
ISSN: 1058-4838
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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