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|Title: ||Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil|
|Other Titles: ||Clinical Infectious Diseases|
|Authors: ||Ko, Albert I.|
Reis, Joice Neves
Coppola, Steven J.
Gouveia, Edilane Lins
Cordeiro, Soraia Machado
Lôbo, Tatiana Silva
Pinheiro, Ricardo M.
Dourado, Cibele M. Ribeiro
Reis, Mitermayer Galvão
Johnson Jr, Warren D.
Riley, Lee W.
|Keywords: ||Streptococcus pneumoniae;Meningitis|
|Issue Date: ||2000|
|Publisher: ||Clinical Infectious Diseases|
|Abstract: ||Active hospital-based surveillance in the city of Salvador, Brazil, from December 1995
through October 1998, identified 221 patients with confirmed pneumococcal meningitis. Of
these 221 patients, 29 (13%) had isolates with intermediate-level resistance to penicillin. Infection
with these penicillin-nonsusceptible isolates was significantly associated with age of
!2 years (P ! .0019), previous antibiotic use (P ! .0006), and coresistance to trimethoprimsulfamethoxazole
(P ! .0000). Serotype 14 was the most prevalent serotype (55.2%) of penicillin-
nonsusceptible isolates. Strain typing by repetitive element BOX polymerase chain reaction
(PCR) analysis showed that penicillin-nonsusceptible serotype 14 isolates had closely
related BOX PCR patterns, whereas penicillin-susceptible serotype 14 isolates each had distinct,
unrelated patterns. Penicillin-nonsusceptible serotype 14 isolates from Salvador and
other Brazilian cities had similar BOX PCR patterns. These observations indicate that in
Brazil a large proportion of cases of penicillin-nonsusceptible pneumococcal meningitis appear
to be caused by a closely related group of serotype 14 strains that may have disseminated to
widely separate geographic areas.|
|Description: ||Texto completo. Acesso restrito. p. 78-86|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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