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|Title: ||Molecular epidemiology of Saint Louis encephalitis virus in the Brazilian Amazon: genetic divergence and dispersal|
|Other Titles: ||Journal of General Virology|
|Authors: ||Rodrigues, Sueli G.|
Nunes, Márcio Roberto Teixeira
Casseb, Samir M. M.
Prazeres, Assis S. C.
Rodrigues, Daniela S. G.
Silva, Mayra O.
Cruz, Ana C. R.
Vasconcelos, Pedro F. C.
|Keywords: ||Molecular Epidemiology;Encephalitis Virus;SaintLouis encephalitis virus (SLEV);Flavivirus|
|Issue Date: ||2010|
|Abstract: ||Saint Louis encephalitis virus (SLEV), a member of the genus Flavivirus (family Flaviviridae), is an encephalitogenic arbovirus broadly distributed in the Americas. Phylogenetic analysis based on the full-length E gene sequences obtained for 30 Brazilian SLEV strains was performed using different methods including Bayesian and relaxed molecular clock approaches. A new genetic lineage was suggested, hereafter named genotype VIII, which co-circulates with the previously described genotype V in the Brazilian Amazon region. Genotypes II and III were restricted to São Paulo state (South-east Atlantic rainforest ecosystem). The analysis also suggested the emergence of an SLEV common ancestor between 1875 and 1973 (mean of 107 years ago), giving rise to two major genetic groups: genotype II, more prevalent in the North America, and a second group comprising the other genotypes (I and III–VIII), broadly dispersed throughout the Americas, suggesting that SLEV initially emerged in South America and spread to North America. In conclusion, the current study demonstrates the high genetic variability of SLEV and its geographical dispersion in Brazil and other New World countries.|
|Description: ||Texto completo: acesso restrito. p.2420-2427|
|Appears in Collections:||Artigos Publicados em Periódicos (Medicina)|
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