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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/12357

Title: Laser and LED phototherapies on angiogenesis
Other Titles: Lasers in Medical Science
Authors: Sousa, Ana Paula Cavalcanti de
Paraguassú, Gardênia Matos
Silveira, Nara Tayene Teixeira
Souza, José de
Cangussu, Maria Cristina Teixeira
Santos, Jean Nunes dos
Pinheiro, Antonio Luiz Barbosa
Keywords: Blood vessels;Healing;Light therapy
Issue Date: 2013
Publisher: Lasers in Medical Science
Abstract: Angiogenesis is a key process for wound healing. There are few reports of LED phototherapy on angiogenesis, mainly in vivo. The aim of the present investigation was to evaluate histologically the angiogenesis on dorsal cutaneous wounds treated with laser (660 and 790 nm) or LEDs (700, 530, and 460 nm) in a rodent model. Twenty-four young adult maleWistar ratsweighting between 200 and 250gwere used on the present study. Under general anesthesia, one excisional wound was created on the dorsum of each animal that were then randomly distributed into six groups with four animals each: G0—control; G1—laser λ660 nm (60 mW, ϕ ∼2 mm, 10 J/cm2); G2—laser λ790 nm (50 mW, ϕ ∼2 mm, 10 J/cm2); G3—LED λ700±20 nm (15mW, ϕ ∼16 mm, 10 J/cm2); G4— LED λ530±20 nm (8 mW, ϕ ∼16 mm, 10 J/cm2); G5—LED λ460±20 nm(22mW, ϕ ∼16 mm, 10 J/cm2). Irradiation started immediately after surgery and was repeated every other day for 7 days. Animal death occurred at the eighth day after surgery. The specimens were removed, routinely processed to wax, cut and stained with HE. Angiogenesis was scored by blood vessel counting in the wounded area. Quantitative results showed that green LED (λ530±20 nm), red LED (λ700±20 nm), λ790 nm laser and λ660 nm laser caused significant increased angiogenesis when compared to the control group. It is concluded that both laser and LED light are capable of stimulating angiogenesis in vivo on cutaneous wounds and that coherence was not decisive on the outcome of the treatment.
Description: Texto completo. Acesso restrito. p. 981-987
URI: http://www.repositorio.ufba.br/ri/handle/ri/12357
ISSN: 0268-8921
Appears in Collections:Artigos Publicados em Periódicos (Odontologia)

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