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Title: Biochemical and Immunologic predictors of efficacy of treatment or reinfection risk fo Schistosoma Mansoni
Other Titles: The American Society of Tropical Medicine and Hygiene
Authors: Reis, Eliana A. G.
Reis, Mitermayer Galvão dos
Silva, Rita de Cássia R.
Carmo, Theomira Mauadie Azevedo
Assis, Ana Marlucia de Oliveira
Barreto, Mauricio Lima
Parraga, Isabel M.
Santana, Mônica Leila Portela de
Blanton, Ronald Edward
Keywords: Lipoproteins;Oxamniquine
Issue Date: 2006
Abstract: Most Schistosoma mansoni infections are egg-negative after a single dose of oxamniquine. A cohort of 661 infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection (100 versus 65 eggs/g, P = 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL, P = 0.045). The biologic plausibility of this observation is discussed.
Description: Texto completo: acesso restrito. p.904–909
URI: http://www.repositorio.ufba.br/ri/handle/ri/12151
ISSN: 0002-9637
Appears in Collections:Artigos Publicados em Periódicos (Nutrição)

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