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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/12103
Tipo: Artigo de Periódico
Título: Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis
Título(s) alternativo(s): Pediatric Diabetes
Autor(es): Alves, Crésio de Aragão Dantas
Lima, Daniela Seabra
Cardeal, Mauricio
Santana, Angelica
Autor(es): Alves, Crésio de Aragão Dantas
Lima, Daniela Seabra
Cardeal, Mauricio
Santana, Angelica
Abstract: Objective: To evaluate glucose tolerance in racially mixed Brazilian youth with cystic fibrosis (CF). Methods: Cross-sectional study conducted between August and September 2007, at a reference service for CF, evaluating: glycated hemoglobin (HbA1c), blood glucose, and insulin levels, before and 2 h after a glucose overload. Results: There were 46 patients aged between 6 yr and 16 yr and 2 months (median: 9 yr and 10 months) of whom 64% were boys. Of these, 26% were Whites; 54.4% Mulattoes; and 19.6% Blacks. HbA1c was normal in all patients. Only one participant (12-yr old) had glucose intolerance. Insulin levels ranged from 1 to 23 µIU/mL (median: 4.5 µIU/mL) at baseline and from 3.2 to 192.1 µIU/mL (median: 11 µIU/mL) after a glucose overload. Insulin resistance evaluated by the HOMA index, stratified by sex and age, was present in three patients. The ΔF508 mutation was present in only 4.3% of the sample, all of them being heterozygous. Conclusions: The low prevalence of carbohydrate intolerance in this population is probably a result of their young age. Another possibility is the low frequency of the ΔF508 mutation. Although not conclusive, these data suggest that in addition to age, the genotype:phenotype ratio may influence the development of glucose intolerance in patients with CF.
Palavras-chave: Cystic fibrosis
Diabetes mellitus
Glucose intolerance
Race/ethnicity
URI: http://www.repositorio.ufba.br/ri/handle/ri/12103
Data do documento: Nov-2010
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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