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|Title: ||Asthma cases in childhood attributed to atopy in tropical area in Brazil|
|Other Titles: ||Pan American Journal of Public Health / Revista Panamericana de Salud Pública|
|Authors: ||Cunha, Sérgio Souza da|
Barreto, Mauricio Lima
Fiaccone, Rosemeire Leovigildo
Cooper, Philip J.
Alcântara-Neves, Neuza Maria
Simões, Silvia de Magalhães
Cruz Filho, Álvaro Augusto Souza da
Rodrigues, Laura Cunha
|Keywords: ||Asthma;atopic hypersensitivity;child;Brazil|
|Issue Date: ||2010|
|Abstract: ||OBJECTIVE: This study aimed to explore the association between asthma and atopy in a cohort of children living in a large urban center in Brazil. Atopy was defined by the presence of allergen-specific IgE in serum or by a positive skin prick test.
METHODS: In a sample of 1 445 Brazilian children, the association between the prevalence of asthma, skin prick test positivity, and allergen-specific IgE in serum was investigated.
RESULTS: The prevalence of asthma was 22.6%. The presence of serum allergen-specific IgE was frequent in asthmatics and nonasthmatics, and the prevalence of asthma increased only with levels of allergen-specific IgE > 3.5 kilounits/L. The proportion of asthma attributable to atopy was estimated to be 24.5% when atopy was defined by the presence of allergen-specific IgE. With a given level of specific IgE, no association between skin test reactivity and asthma was observed. Skin prick tests were less sensitive than specific IgE for detection of atopy.
CONCLUSIONS: Most asthma cases in an urban underprivileged setting in Brazil were not attributable to atopy. This observation has important implications for understanding the risk factors for the asthma epidemic in Latin America.|
|Description: ||Texto completo: acesso restrito. p.405-411|
|Appears in Collections:||Artigos Publicados em Periódicos Estrangeiros (ISC)|
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