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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/8386
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dc.contributor.authorBomfim, Glória-
dc.contributor.authorNascimento, Cristiane Santos-
dc.contributor.authorCosta, Jackson-
dc.contributor.authorCarvalho Filho, Edgar Marcelino de-
dc.contributor.authorBarral-Netto, Manoel-
dc.contributor.authorBarral, Aldina Maria Prado-
dc.creatorBomfim, Glória-
dc.creatorNascimento, Cristiane Santos-
dc.creatorCosta, Jackson-
dc.creatorCarvalho Filho, Edgar Marcelino de-
dc.creatorBarral-Netto, Manoel-
dc.creatorBarral, Aldina Maria Prado-
dc.date.accessioned2013-02-06T13:47:54Z-
dc.date.issued1996-
dc.identifier.issn0014-4894-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/8386-
dc.descriptionTexto completo: acesso restrito. p.188–194pt_BR
dc.description.abstractDiffuse cutaneous leishmaniasis is a rare entity characterized by disseminated cutaneous nodules associated with specific anergy to leishmanial antigens. A low but not absent IFN-γ expression by cells present in cutaneous lesions has been documented during the active phase of diffuse cutaneous leishmaniasis. In this study we confirm this observation, and extend it by showing a similar pattern in peripheral blood mononuclear cells and the variation of mRNA cytokine expression pattern during different stages of the disease. During active disease, patients did not express mRNA for IFN-γ, while expressing mRNA for IL-2, IL-4, and IL-10. In contrast, an expression of IFN-γ and low IL-10 was observed after treatment-induced transient healing of cutaneous lesions. In three patients we have been able to analyze a third PBMC sample obtained after clinical relapse, documenting in all of them decreased IFN-γ expression with no expression of IL-10. Although there was an association between the appearance of IFN-γ expression and clinical improvement, with marked expression of IFN-γ mRNA and decreased expression of mRNA for IL-10 after treatment, this was not sufficient to prevent relapse in these patients. Therefore, it is possible that factors other than the cytokines characteristic of the Th1 and Th2 balance are implicated in the inability of diffuse cutaneous leishmaniasis patients to mount an anti-Leishmaniaimmune response causing clinical improvement.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://dx.doi.org/10.1006/expr.1996.0104pt_BR
dc.subjectleishmaniasispt_BR
dc.subjectcytokinespt_BR
dc.subjecttherapypt_BR
dc.subjectcutaneous leishmaniasispt_BR
dc.subjectDCLpt_BR
dc.subjectdiffuse cutaneous leishmaniasispt_BR
dc.subjectIFN-γpt_BR
dc.subjectinterferon-gammapt_BR
dc.subjectILpt_BR
dc.subjectinterleukinpt_BR
dc.subjectPBMCpt_BR
dc.subjectperipheral blood mononuclear cellspt_BR
dc.subjectDEPCpt_BR
dc.subjectPCRpt_BR
dc.subjectdiethylpyrocarbonatept_BR
dc.subjectpolymerase chain reactionpt_BR
dc.titleVariation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasispt_BR
dc.title.alternativeExperimental Parasitologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 84, n. 2pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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