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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/7804
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dc.contributor.authorCampos Neto, Antonio-
dc.contributor.authorRodrigues Júnior, V.-
dc.contributor.authorSampaio, D. B. Pedral-
dc.contributor.authorM. Netto, E.-
dc.contributor.authorOvendale, P. J.-
dc.contributor.authorColer, R. N.-
dc.contributor.authorSkeiky, Y. A. W.-
dc.contributor.authorBadaró, Roberto José da Silva-
dc.contributor.authorReed, Steven G.-
dc.creatorCampos Neto, Antonio-
dc.creatorRodrigues Júnior, V.-
dc.creatorSampaio, D. B. Pedral-
dc.creatorM. Netto, E.-
dc.creatorOvendale, P. J.-
dc.creatorColer, R. N.-
dc.creatorSkeiky, Y. A. W.-
dc.creatorBadaró, Roberto José da Silva-
dc.creatorReed, Steven G.-
dc.date.accessioned2013-01-11T11:25:46Z-
dc.date.issued2001-
dc.identifier.issn1472-9792-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/7804-
dc.descriptionTexto completo: acesso restrito. p. 353–358pt_BR
dc.description.abstractAlthough the tuberculin test has aided in the diagnosis of tuberculosis for more than 85 years, its interpretation is difficult particularly because sensitization with non-tuberculous mycobacteria leads to false positive tests. Using the guinea pig model of tuberculosis, we have recently described a recombinant antigen (DPPD) that could circumvent this problem. The DPPD gene is unique to the M. tuberculosis complex organisms and is absent in the organisms representative of all other members of the Mycobacterium genus. Moreover, DPPD induced strong DTH in 100% of the guinea pigs infected with M. tuberculosis and in none of the guinea pigs immunized with nine different species of Mycobacterium. Here we present results of a clinical investigation using DPPD. Mantoux test using both PPD and DPPD was initially performed in 26 patients with confirmed pulmonary tuberculosis and in 25 healthy PPD negative individuals. The results indicated that both PPD and DPPD elicited DTH in 24 out of the 26 patients. No DTH was observed in any of the PPD negative individuals. In addition, a small clinical trial was performed in a population of 270 clinically healthy and randomly selected individuals. DPPD produced a bimodal histogram of skin reaction size and PPD produced a skewed histogram. Because the DPPD gene is not present in non-tuberculous bacilli, these results suggest that this molecule can be an additional tool for a more specific diagnosis of tuberculosis.pt_BR
dc.language.isoenpt_BR
dc.sourcehttp://dx.doi.org/10.1054/tube.2001.0311pt_BR
dc.titleEvaluation of DPPD, a single recombinant Mycobacterium tuberculosis protein as an alternative antigen for the Mantoux testpt_BR
dc.title.alternativeTuberculosispt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 81, n. 5-6pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (FIS)

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