Campo DC | Valor | Idioma |
dc.contributor.author | Santos, Silvane Maria Braga | - |
dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.contributor.author | Muniz, André Luís Nunes | - |
dc.contributor.author | Jesus, Amélia Ribeiro de | - |
dc.contributor.author | Magalhães, Elza | - |
dc.contributor.author | Melo, Ailton de Souza | - |
dc.contributor.author | Dutra, Walderez Ornelas | - |
dc.creator | Santos, Silvane Maria Braga | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Muniz, André Luís Nunes | - |
dc.creator | Jesus, Amélia Ribeiro de | - |
dc.creator | Magalhães, Elza | - |
dc.creator | Melo, Ailton de Souza | - |
dc.creator | Dutra, Walderez Ornelas | - |
dc.date.accessioned | 2013-01-04T12:44:24Z | - |
dc.date.available | 2013-01-04T12:44:24Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7744 | - |
dc.description | p. 1-8 | pt_BR |
dc.description.abstract | Background: A small fraction of Human T cell Leukemia Virus type-1 (HTLV-I) infected subjects develop a severe form of myelopathy. It has been established that patients with HTLV-I associated myelopathy/tropical spastic paraparesis
(HAM/TSP) show an exaggerated immune response when compared with the immunological response observed in
HTLV-I asymptomatic carriers. In this study the immunological responses in HAM/TSP patients and in HTLV-I asymptomatic carriers were compared using several immunological assays to identify immunological markers associated with progression from infection to disease. Methods: Immunoproliferation assays, cytokine levels of unstimulated cultures, and flow cytometry analysis were used to evaluate the studied groups. Nonparametric tests (Mann-Whitney U test and Wilcoxon matched-pairs signed ranks)
were used to compare the difference between the groups.Results: Although both groups showed great variability, HAM/TSP patients had higher spontaneous lymphoproliferation
as well as higher IFN-γ levels in unstimulated supernatants when compared with asymptomatic carriers. Flow cytometry
studies demonstrated a high frequency of inflammatory cytokine (IFN-γ and TNF-α) producing lymphocytes in HAM/TSP
as compared to the asymptomatic group. This difference was accounted for mainly by an increase in CD8 cell production
of these cytokines. Moreover, the HAM/TSP patients also expressed an increased frequency of CD28-/CD8+ T cells.
Since forty percent of the asymptomatic carriers had spontaneous lymphoproliferation and IFN-γ production similar to
HAM/TSP patients, IFN-γ levels were measured eight months after the first evaluation in some of these patients to observe if this was a transient or a persistent situation. No significant difference was observed between the means of IFN-γ levels in the first and second evaluation.Conclusions: The finding that a large proportion of HTLV-I carriers present similar immunological responses to those observed in HAM/TSP, strongly argues for further studies to evaluate these parameters as markers of HAM/TSP progression. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://www.biomedcentral.com/1471-2334/4/7 | pt_BR |
dc.title | Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers | pt_BR |
dc.title.alternative | BMC Infectious Diseases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 4, n. 7 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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