https://repositorio.ufba.br/handle/ri/7600
Campo DC | Valor | Idioma |
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dc.contributor.author | Balestieri, Filomena Maria Perrella | - |
dc.contributor.author | Queiroz, Allan Rêgo Pires | - |
dc.contributor.author | Scavone, Cristoforo | - |
dc.contributor.author | Costa, Vlaudia Maria Assis | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Abrahamsohn, Ises de Almeida | - |
dc.creator | Balestieri, Filomena Maria Perrella | - |
dc.creator | Queiroz, Allan Rêgo Pires | - |
dc.creator | Scavone, Cristoforo | - |
dc.creator | Costa, Vlaudia Maria Assis | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Abrahamsohn, Ises de Almeida | - |
dc.date.accessioned | 2012-12-17T15:44:52Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1286-4579 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7600 | - |
dc.description | Texto completo: acesso restrito. p. 23–29 | pt_BR |
dc.description.abstract | Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis promastigotes. The downmodulation of NO production observed in infected and LPS-stimulated J774-G8 cells correlated with a reduction in inducible nitric oxide synthase (iNOS) activity. Reduction in iNOS activity was not paralleled by decreased iNOS mRNA expression, suggesting that the parasite affects post-transcriptional events of NO synthesis. Supplementation with L-arginine or tetrahydrobiopterin did not increase NO production, suggesting that inhibition is not due to an insufficiency of substrate or co-factor. Treatment with anti-IL-10, anti-IL-4 or anti-TGF-β neutralizing antibodies also failed to increase NO production, indicating that these cytokines are not involved in the observed parasite-induced inhibition of NO synthesis. However, treatment of the cultures with IFN-γ resulted in a marked increase in NO production by infected LPS-stimulated cells. These results show that although L.(L.) amazonensis infection inhibits iNOS activity and NO production by J774-G8 cells, activation by IFN-γ is capable of overriding the suppression of NO synthesis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1016/S1286-4579(01)01505-2 | pt_BR |
dc.subject | Leishmania (L.) amazonensis | pt_BR |
dc.subject | Macrophage | pt_BR |
dc.subject | Nitric oxide | pt_BR |
dc.subject | iNOS activity | pt_BR |
dc.subject | iNOS mRNA | pt_BR |
dc.subject | IFN-γ | pt_BR |
dc.title | Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages | pt_BR |
dc.title.alternative | Microbes and Infection | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 4, n. 1 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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1-s2.0-S1286457901015052-main.pdf Restricted Access | 136,24 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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