https://repositorio.ufba.br/handle/ri/7437
Campo DC | Valor | Idioma |
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dc.contributor.author | Bacellar, Maria Olívia Amado Ramos | - |
dc.contributor.author | Lessa, Hélio Andrade | - |
dc.contributor.author | Schriefer, Nicolaus Albert Borges | - |
dc.contributor.author | Machado, Paulo Roberto Lima | - |
dc.contributor.author | Jesus, Amélia Ribeiro de | - |
dc.contributor.author | Dutra, Walderez Ornelas | - |
dc.contributor.author | Gollob, Kenneth John | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Bacellar, Maria Olívia Amado Ramos | - |
dc.creator | Lessa, Hélio Andrade | - |
dc.creator | Schriefer, Nicolaus Albert Borges | - |
dc.creator | Machado, Paulo Roberto Lima | - |
dc.creator | Jesus, Amélia Ribeiro de | - |
dc.creator | Dutra, Walderez Ornelas | - |
dc.creator | Gollob, Kenneth John | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2012-12-12T10:46:55Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7437 | - |
dc.description | Texto completo: acesso restrito. p. 6734–6740 | pt_BR |
dc.description.abstract | The cytokine profile produced by peripheral blood mononuclear cells (PBMC) in response to leishmania antigens and the ability of interleukin-10 (IL-10) and transforming growth factor β (TGF-β) to modulate the immune response were evaluated in 21 mucosal leishmaniasis patients. Patients with mucosal disease exhibited increased gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) secretion and decreased IL-10 secretion compared to patients with classical cutaneous leishmaniasis. CD4+ Th1 cells were the main source of IFN-γ and TNF-α production in mucosal leishmaniasis patients. Evaluation of cytokine gene expression in PBMC of these patients showed that there was strong up-regulation of IFN-γ transcripts upon stimulation with leishmania antigen, in contrast to the baseline levels of IL-10 mRNA. IL-10 suppressed IFN-γ production by 48% in cell cultures from cutaneous leishmaniasis patients and by 86% in cell cultures from healthy subjects stimulated with purified protein derivative, whereas in similar conditions IL-10 suppressed IFN-γ production by 19% in cell cultures from mucosal leishmaniasis patients stimulated with leishmania antigen. TGF-β suppressed IFN-γ levels to a greater extent in healthy subjects than in mucosal leishmaniasis and cutaneous leishmaniasis patients. These data indicate that a poorly modulated T-cell response in mucosal leishmaniasis patients leads to production of high levels of proinflammatory cytokines, such as IFN-γ and TNF-α, as well as a decreased ability of IL-10 and TGF-β to modulate this response. These abnormalities may be the basis for the pathological findings observed in this disease. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1128/IAI.70.12.6734-6740.2002 | pt_BR |
dc.title | Up-regulation of th1-type responses in mucosal leishmaniasis patients | pt_BR |
dc.title.alternative | Infection and Immunity | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 70, n. 12 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (PPGCS) |
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6734.full.pdf Restricted Access | 257,27 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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