https://repositorio.ufba.br/handle/ri/7400
metadata.dc.type: | Artigo de Periódico |
Title: | The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide |
Other Titles: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis |
Authors: | Salvadori, Daisy M. F. Ribeiro, Lúcia R. Oliveira, Marília de Dirceu Machado de Pereira, Carlos A. B. Beçak, Willy |
metadata.dc.creator: | Salvadori, Daisy M. F. Ribeiro, Lúcia R. Oliveira, Marília de Dirceu Machado de Pereira, Carlos A. B. Beçak, Willy |
Abstract: | The influence of ß-carotene on the clastogenicity of the indirect-acting mutagen cyclophosphamide (CPA) was investigated in mice, in vivo, for the induction of chromosome aberrations in bone marrow cells (BM). ß-Carotene (0.5, 1.0, 2.0, 5.0, 10, 25, 50, 100 and 200 mg/kg) was administered by gavage for 5 consecutive days. 4 h after the last treatment with ß-carotene, the mice were injected intraperitoneally with CPA, and the BM cells were fixed after 16, 24 and 32 h for the evaluation of the frequency of chromosome aberrations. The results showed that ß-carotene was effective in reducing chromosomal damage induced by CPA with the increase of its concentration up to a level after which this effect was not observed. This anticlastogenicity was better detected when the cells were fixed at 32 h, although a tendency in reducing the CPA clastogenicity was already observed at 16 and 24 h. Our results suggest that ß-carotene provides significant protection against the genotoxicity of CPA, although no dose-effect relationship on the frequencies of cells with chromosomal aberrations was observed. |
Keywords: | Antimutagenesis ß-Carotene Chromosome aberration Cyclophosphamide |
Publisher: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7400 |
Issue Date: | 1992 |
Appears in Collections: | Artigo Publicado em Periódico (EMV) |
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rrrrr56565.pdf | 514,85 kB | Adobe PDF | View/Open |
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