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dc.contributor.authorMagrani, Janeide-
dc.contributor.authorSilva, Emilio de Castro e-
dc.contributor.authorVarjão, Bruno-
dc.contributor.authorDuarte, Gleison Vieira-
dc.contributor.authorRamos, Ana Claudia-
dc.contributor.authorAthanazio, Rodrigo Abensur-
dc.contributor.authorBarbetta, Marcelo Campos-
dc.contributor.authorLuz, Patricia-
dc.contributor.authorFregoneze, Josmara Bartolomei-
dc.creatorMagrani, Janeide-
dc.creatorSilva, Emilio de Castro e-
dc.creatorVarjão, Bruno-
dc.creatorDuarte, Gleison Vieira-
dc.creatorRamos, Ana Claudia-
dc.creatorAthanazio, Rodrigo Abensur-
dc.creatorBarbetta, Marcelo Campos-
dc.creatorLuz, Patricia-
dc.creatorFregoneze, Josmara Bartolomei-
dc.date.accessioned2012-11-08T19:32:37Z-
dc.date.issued2004-
dc.identifier.issn0091-3057-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/7155-
dc.descriptionp. 189-198pt_BR
dc.description.abstractThe aim of the present study was to investigate the effect of the pharmacological blockade of histamine H1 and H2 receptors located within the ventromedial hypothalamus (VMH) on overnight food and water intake and on water intake elicited by two physiological stimuli: hyperosmolarity induced by an acute intragastric salt load and water deprivation. During the overnight period, the pharmacological blockade of both H1 and H2 VMH receptors significantly increased food intake and decreased water intake. In hyperosmotic rats, the blockade of H1 VMH receptors reduced water intake, while the blockade of H2 receptors in this same region yielded no significant effect. Additionally, in water-deprived rats, the blockade of both H1 and H2 receptors located within the VMH induced a significant decrease in water intake. The inhibitory effects on drinking behavior observed in this study do not seem to be a consequence of any billness-inducingQ effect provoked by the central administration of the antihistaminergic agents employed here, because an aversion test indicated that the injection of those compounds into the VMH does not induce any billness-likeQ effect. In addition, the central administration of either mepyramine or cimetidine to dehydrated and hyperosmotic rats did not produce any reduction in locomotor activity measured in an openfield arena. Injections of the antihistaminergic agents used here into the regions that circumscribe the VMH produced no significant effects on water or food intake, indicating that the actions observed here may be specifically attributed to the set of histaminergic receptors situated within the VMH.pt_BR
dc.language.isoenpt_BR
dc.publisherElsevierpt_BR
dc.sourcehttp://dx.doi.org/10.1016/j.pbb.2004.07.004pt_BR
dc.subjectWater intakept_BR
dc.subjectFood intakept_BR
dc.subjectVentromedial hypothalamuspt_BR
dc.subjectThirstpt_BR
dc.subjectCimetidinept_BR
dc.subjectMepyraminept_BR
dc.subjectH1 receptorpt_BR
dc.subjectH2 receptorpt_BR
dc.titleHistaminergic H1 and H2 receptors located within the ventromedial hypothalamus regulate food and water intake in ratspt_BR
dc.title.alternativePharmacology Biochemistry and Behaviorpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 79, n. 1pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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