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Campo DC | Valor | Idioma |
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dc.contributor.author | Atta, Ajax Mercês | - |
dc.contributor.author | Sousa, C. P. | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Atta, Maria Luiza Brito de Sousa | - |
dc.creator | Atta, Ajax Mercês | - |
dc.creator | Sousa, C. P. | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Atta, Maria Luiza Brito de Sousa | - |
dc.date.accessioned | 2012-11-07T13:03:25Z | - |
dc.date.available | 2012-11-07T13:03:25Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1414-431X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7131 | - |
dc.description | p. 1497-1501 | pt_BR |
dc.description.abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by intense polyclonal production of autoantibodies and circulating immune complexes. Some reports have associated SLE with a Th2 immune response and allergy. In the present study 21 female patients with SLE were investigated for total IgE and IgE antibodies to dust house aeroallergens by an automated enzyme-linked fluorescent assay, and were also evaluated for antinuclear IgE autoantibodies by a modified indirect immunofluorescence test using HEp-2 cells as antigen substrate. Additionally, immunocapture ELISA was used to investigate serum anti-IgE IgG autoantibodies. Serum IgE above 150 IU/ml, ranging from 152 to 609 IU/ml (median = 394 IU IgE/ml), was observed in 7 of 21 SLE patients (33%), 5 of them presenting proteinuria, urinary cellular casts and augmented production of anti-dsDNA antibodies. While only 2 of 21 SLE patients (9.5%) were positive for IgE antibodies to aeroallergens, all 10 patients with respiratory allergy (100%) from the atopic control group (3 males and 7 females), had these immunoglobulins. SLE patients and healthy controls presented similar anti-IgE IgG autoantibody titers (X = 0.37 ± 0.20 and 0.34 ± 0.18, respectively), differing from atopic controls (0.94 ± 0.26). Antinuclear IgE autoantibodies were detected in 17 of 21 (81%) sera from SLE patients, predominating the fine speckled pattern of fluorescence, that was also observed in IgG-ANA. Concluding, SLE patients can present increased IgE levels and antinuclear IgE autoantibodies without specific clinical signs of allergy or production of antiallergen IgE antibodies, excluding a possible association between SLE and allergy. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1590/S0100-879X2004001000008 | pt_BR |
dc.subject | Systemic lupus erythematosus | pt_BR |
dc.subject | Antinuclear IgE antibody | pt_BR |
dc.subject | Allergy | pt_BR |
dc.subject | IgG anti-IgE | pt_BR |
dc.subject | IgE | pt_BR |
dc.title | Immunoglobulin E and systemic lupus erythematosus | pt_BR |
dc.title.alternative | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Ribeirão Preto | pt_BR |
dc.identifier.number | v. 37, n. 10 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (FAR) |
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__www.scielo.br_pdf_bjmbr_v37n10_5126.pdf | 105,78 kB | Adobe PDF | Visualizar/Abrir |
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