https://repositorio.ufba.br/handle/ri/7036
Tipo: | Artigo de Periódico |
Título: | Cytokine profile and pathology in human leishmaniasis |
Título(s) alternativo(s): | Brazilian Journal of Medical and Biological Research |
Autor(es): | Jesus, A. Ribeiro de Almeida, Roque Pacheco de Lessa, Hélio Andrade Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de |
Autor(es): | Jesus, A. Ribeiro de Almeida, Roque Pacheco de Lessa, Hélio Andrade Bacellar, Maria Olívia Amado Ramos Carvalho Filho, Edgar Marcelino de |
Abstract: | The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN- is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN- production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN- production and enhances the cytotoxic response. IL-10 is the cytokine involved in down-regulation of IFN- production, since anti-IL-10 monoclonal antibody (mAb) restores in vitro IFN- production and lymphoproliferative responses, and IL-10 abrogates the effect of IL-12. In cutaneous and mucosal leishmaniasis, high levels of IFN- are found in L. amazonensis-stimulated PBMC. However, low or absent IFN- levels were observed in antigen-stimulated PBMC from 50% of subjects with less than 60 days of disease (24 ± 26 pg/ml). This response was restored by IL-12 (308 ± 342 pg/ml) and anti-IL-10 mAb (380 ± 245 pg/ml) (P<0.05). Later during the disease, high levels of IFN- and TNF- are produced both in cutaneous and mucosal leishmaniasis. After treatment there is a decrease in TNF- levels (366 ± 224 pg/ml before treatment vs 142 ± 107 pg/ml after treatment, P = 0.02). Although production of IFN- and TNF- might be involved in the control of parasite multiplication in the early phases of Leishmania infection, these cytokines might also be involved in the tissue damage seen in tegumentary leishmaniasis. |
Palavras-chave: | Leishmaniasis Human leishmaniasis Cytokines Pathology Immunological responses |
Editora / Evento / Instituição: | Brazilian Journal of Medical and Biological Research |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7036 |
Data do documento: | 1998 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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Ribeiro-de-Jesus, A.pdf | 221,49 kB | Adobe PDF | Visualizar/Abrir |
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